Ácidos grasos omega-3 y función endotelial en pacientes con síndrome coronario agudo

Maricela  Ramírez Salazar; Sara  Brito; Mary  Lares; Carlos  Maiorana; Jorge  Castro

Omega-3 fatty acids and endothelial function in patients with acute coronary syndrome

Authors

Maricela Ramírez Salazar Hospital Central de las Fuerzas Armadas, República Dominicana https://orcid.org/0000-0003-0053-6019
Sara Brito Hospital Militar Universitario “Dr. Carlos Arvelo”, Venezuela
Mary Lares Universidad Central de Venezuela, Venezuela https://orcid.org/0000-0002-2945-6541
Carlos Maiorana Universidad Católica de Murcia, España https://orcid.org/0000-0002-5734-2170
Jorge Castro Hospital Universitario Militar “Dr. Carlos Arvelo, Venezuela https://orcid.org/0000-0002-1676-1723

Abstract

Mainly as coronary ischemic disease. e prognosis and outcome of Acute Coronary Syndrome (ACS) depend largely on the endothelial dysfunction associated with this condition. Objective: To evaluate the effect of omega-3 fatty acids on endothelial function in Acute Coronary Syndrome (ACS). Method: A study was conducted with 16 patients with acute coronary syndrome (ACS) treated with Omega-3 at a dose of 3 grams/day+Conventional Therapy (O3+Tc) for 30 days. Lipid profile, ultrasensitive C-reactive protein (usCRP), Endothelin 1 (ET-1), and Brain Natriuretic Peptide (NTproBNP) were performed 12 hours after admission and 30 days later. Results: During 4 weeks of follow-up, the use of 3 grams/day of omega-3 fatty acids, added to conventional therapy in Acute Coronary Syndrome, showed a significant reduction in the plasma concentration of NTproBNP (p = 0.000), hsCRP (p =0.000) and Triglycerides (p = 0.004). Conclusion: Three grams a day of omega-3 fatty acids contributes to the reduction of the plasmatic concentration of Triglycerides and NTproBNP in patients with acute coronary syndrome.

Keywords: Omega-3 Fatty Acids, Acute coronary syndrome, Endothelial function, Conventional therapy.

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Published

2022-08-22

How to Cite

Ramírez Salazar, M. ., Brito, S. ., Lares, M. ., Maiorana, C. ., & Castro, J. . (2022). Omega-3 fatty acids and endothelial function in patients with acute coronary syndrome. Revista Digital De Postgrado, 11(2), e340. Retrieved from http://caelum.ucv.ve/ojs/index.php/rev_dp/article/view/24299

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Issue

Vol. 11 No. 2 (2022): Revista Digital de Postgrado. May-Ago

Section

ORIGINAL ARTICLE

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