Fisiopatología de la hipertensión arterial: ¿Qué hay de nuevo?

Abstract

Hypertension (HT) represents the leading cause of cardiovascular disease and premature death globally. Knowledge regarding the pathogenesis of HT has greatly grown; nevertheless, obscure areas remain concerning this topic. At present, multiple renal, neurologic, endocrine, immunologic, and cardiovascular mechanisms are known to affect cardiovascular homeostasis, generating an intricate and complex conglomerate of pathophysiologic mechanisms. Despite advancements in recent years, the current pharmacological armamentarium remains insufficient for the management of all patients. Likewise, recent research concentrates on the identification of premorbid mechanisms, intending to identify therapeutic targets to delay the onset of HT as much as possible in high-risk populations. The objective of this review is to evaluate novel finding regarding the origin of HT, aiming to offer new mechanisms of intervention for future pharmacologic and non-pharmacologic therapeutic strategies.