Efectos a corto plazo del tratamiento con insulina, sobre los índices hematimétricos en diabéticos

Jesús Hernández

Authors

Jesús Hernández Universidad Central de Venezuela, Venezuela https://orcid.org/0000-0001-7393-358X

Keywords:

Índices hematimétricos, Insulina, Diabetes

Abstract

Objective: To evaluate the short-term effect of insulin treatment on hematimetric indices in type 2 diabetic adult subjects. Methodology: It was a retrospective study, where hematimetric indices and glycemia of 44 hospitalized patients (24 male), 58.7 ± 4.4 years old, type 2 diabetics, were recorded before and aer 6 ± 2 hours of insulin treatment. Results: no statistically significant differences were found between the hematimetric indices before and aer treatment and neither between the sexes. Basal glycemia correlated with red blood cell count (r = 0,417; . = 0,03), mean corpuscular volume (r = 0,424; . = 0,04), hemoglobin (r = 0,626; . = 0,001), hematocrit (r = 0,574; . = 0,005), and mean corpuscular hemoglobin (r=0,537; .=0,01). When dividing the sample into two groups, taking into account the median value of the difference in glycemia before and aer treatment (G1: < 139 mg/dL and G2

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References

Loyola-Leyva A, Loyola-Rodríguez JP, Terán-Figueroa Y, Camacho-Lopez S, González FJ, Barquera S. Application of atomic force microscopy to assess erythrocytes morphology in early stages of diabetes. A pilot study. Micron. 2021; 141:102982. DOI: 10.1016/j.micron.2020.102982. Epub 2020 Nov 7. PMID: 33227627.

Sohn M, Lee JE, Ahn M, Park Y, Lim S. Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks. Sci Rep. 2021;11(1):7007. DOI: 10.1038/s41598-021-86528-0. Erratum in: Sci Rep. 2021 Jul 27;11(1):15633. PMID: 33772071; PMCID: PMC7997877.

Mortaş T, ArikanDurmaz Ş, Sezen ŞC, Savranlar Y. Assessment of erythrocyte morphology in patients with type 2 diabetes mellitus: a pilot study of electron microscopy-based analysis in relation to healthy controls. Turk J Med Sci. 2021;51(5):2534-2542. DOI: 10.3906/sag-2103-336. PMID: 34174794; PMCID: PMC8742505.

Cimbaljević B,Vailijević A, Cimbaljević S, Buzadzić B, KoraćA,Petrović V, et al. Interrelationship of antioxidative status, lipid peroxidation, and lipid profile in insulin-dependent and non-insulin-dependent diabetic patients. Can J Physiol Pharmacol. 2007;85(10):997-1003. DOI:10.1139/y07-088doi:10.1139/y07-088.

Wang Y, Yang P, Yan Z, Liu Z, Ma Q, Zhang Z, et al. The Relationship between Erythrocytes and Diabetes Mellitus. J Diabetes Res. 2021; 2021:6656062. DOI: 10.1155/2021/6656062. PMID: 33728350; PMCID: PMC7935596.

Turpin C, Catan A, Guerin-Dubourg A, Debussche X, Bravo SB, Álvarez E, et al. Enhanced oxidative stress and damage in glycated erythrocytes. PLoS One. 2020;15(7): e0235335. DOI: 10.1371/journal.pone.0235335. PMID: 32628695; PMCID: PMC7337333.

Hernández, J. Índices hematimétricos y enfermedades no hematológicas. Rev Fac Med. [Internet] 2021 [Consultado el 18 de octubre de 2022]; 44(1): 95-121. Disponible en http://saber.ucv.ve/ojs/index.php/rev_fmed/article/view/20496

Suwalsky M, Belmar J, Villena F, Gallardo MJ, Jemiola-Rzeminska M, Strzalka K. Acetylsalicylic acid (aspirin) and salicylic acid interaction with the human erythrocyte membrane bilayer induce in vitro changes in the morphology of erythrocytes. Arch Biochem Biophys. 2013 ;539(1):9-19. PMID: 24055635.

Ghazanfari-Sarabi S, Habibi-Rezaei M, Eshraghi-Naeeni R, Moosavi-Movahedi AA. Prevention of haemoglobin glycation by acetylsalicylic acid (ASA): A new view on old mechanism. PLoS One. 2019;14(4): e0214725. DOI: 10.1371/journal.pone.0214725. PMID: 30986221; PMCID: PMC6464172.

Thiele K, Rau M, Hartmann NK, Möllmann J, Jankowski J, Böhm M, et al. Effects of empagliflozin on erythropoiesis in patients with type 2 diabetes: Data from a randomized, placebo-controlled study. Diabetes Obes Metab. 2021;23(12):2814-2818. DOI: 10.1111/dom.14517. Epub 2021 Aug 25. PMID: 34378852.

Tripathi SS, Singh AK, Akhtar F, Chaudhary A, Rizvi SI. Metformin protects red blood cells against rotenone induced oxidative stress and cytotoxicity. Arch Physiol Biochem. 2019;127(2):102-111. DOI: 10.1080/13813455.2019.1620288. Epub 2019 Jun 1. PMID: 31155970.

Feng L, Chen H, Chen J, Xiong C, Shao X, Wang X, et al. The Product of Red Blood Cells and Hematocrit Can Be Used as a Novel Indicator of Impaired Fasting Blood Glucose Status. Diabetes Metab Syndr Obes. 2020; 13:4007-4015. DOI: 10.2147/DMSO.S270276. PMID: 33149640; PMCID: PMC7602892.

Brands MW. Role of Insulin-Mediated Antinatriuresis in Sodium Homeostasis and Hypertension. Hypertension. 2018;72(6):1255-1262. DOI: 10.1161/HYPERTENSIONAHA.118.11728. PMID: 30571237.

Catalano C, Muscelli E, Natali A, Mazzoni A, Masoni A, Bernardini B, et al. Reciprocal association between insulin sensitivity and the haematocrit in man. Eur J Clin Invest. 1997;27(7):634-637. DOI: 10.1046/j.1365-2362.1997.1770714. x. PMID: 9263753.

Aberle J, Menzen M, Schmid SM, Terkamp C, Jaeckel E, Rohwedder K, et al. Dapagliflozin effects on haematocrit, red blood cell count and reticulocytes in insulin-treated patients with type 2 diabetes. Sci Rep. 2020;10(1):22396. DOI: 10.1038/s41598-020-78734-z. PMID: 33372185; PMCID: PMC7769973.

Biolo G, Massolino B, Di Girolamo FG, Fiotti N, MearelliF, Mazzucco S, et al. Intensive insulin therapy increases glutathione synthesis rate in surgical ICU patients with stress hyperglycemia. PLoS One. 2018;13(1): e0190291. DOI: 10.1371/journal.pone.0190291. PMID: 29300728; PMCID: PMC5754081.

Sharif K, Ghadir S, Jakubowicz D, Amital H, Bragazzi NL, Watad A, Wainstein J, Bar-Dayan Y. Improved outcome of patients with diabetes mellitus with good glycemic control in the cardiac intensive care unit: a retrospective study. Cardiovasc Diabetol. 2019;18(1):4. DOI: 10.1186/s12933-019-0810-8. PMID: 30634972; PMCID: PMC6329158

Pérez A, Ramos A, Carreras G. Insulin Therapy in Hospitalized Patients. Am J Ther. 2020 Jan/Feb;27(1): e71-e78. doi: 10.1097/MJT.0000000000001078. PMID: 31833876.

Chang CH, Wang JL, Wu LC, Chuang LM, Lin HH. Diabetes, Glycemic Control, and Risk of Infection Morbidity and Mortality: A Cohort Study. Open Forum Infect Dis. 2019;6(10): ofz358.DOI: 10.1093/ofid/ofz358. PMID: 31660337; PMCID: PMC6765350

Juhan-Vague I, Roul C, Rahmani-Jourdheil D, Mishal Z, Driss F, Durand-Gasselin M, Aillaud MF, et al. Rapid modifications of biophysical and biochemical parameters of red blood cell membrane from insulin dependent diabetics after insulin administration. Klin Wochenschr. 1986;64(20):1046-1049. PMID: 3023739.

American Diabetes Association Professional Practice Committee: Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, Freeman R, et al. Diabetes Care in the Hospital: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl 1): S244-S253. DOI: 10.2337/dc22-S016. PMID: 34964884.

Michalak SS, Wolny-Rokicka E, Nowakowska E, Michalak M, Gil L. Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly Population. J Diabetes Res. 2021; 2021:8745968. DOI: 10.1155/2021/8745968. PMID: 34708130; PMCID: PMC8545586.

Qadri SM, Bissinger R, Solh Z, Oldenborg PA. Eryptosis in health and disease: A paradigm shifts towards understanding the pathophysiological implications of programmed cell death of erythrocytes. Blood Rev. 2017;31(6):349-361. DOI: 10.1016/j.blre.2017.06.001. Epub 2017 Jun 17. PMID: 28669393.

Bissinger R, Bhuyan AAM, Qadri SM, Lang F. Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases. FEBS J. 2019;286(5):826-854. DOI: 10.1111/febs.14606. Epub 2018 Aug 18. PMID: 30028073.

Pretorius E, du Plooy JN, Bester J. A Comprehensive Review on Eryptosis. Cell Physiol Biochem. 2016;39(5):1977-2000. DOI: 10.1159/000447895. Epub 2016 Oct 24. PMID: 27771701.

Oshima M, Hara A, Toyama T, Jun M, Pollock C, Jardine M, Harrap S, Poulter N, Cooper ME, Woodward M, Chalmers J, Perkovic V, Wong MG, Wada T. Comparison of Circulating Biomarkers in Predicting Diabetic Kidney Disease Progression With Autoantibodies to Erythropoietin Receptor. Kidney Int Rep. 2020; 6(2):284-295. DOI: 10.1016/j.ekir.2020.10.039. PMID: 33615053; PMCID: PMC7879109.

Blaslov K, Kruljac I, Mirošević G, Gaćina P, Kolonić SO, Vrkljan M. The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus. Clin Hemorheol Microcirc. 2019;71(4):475-481. PMID: 30103306.

Alamri BN, Bahabri A, Aldereihim AA, Alabduljabbar M, Alsubaie MM, Alnaqeb D, et al. Hyperglycemia effect on red blood cells indices. Eur Rev Med Pharmacol Sci. 2019; 23(5):2139-2150. DOI: 10.26355/eurrev_201903_17259. PMID: 30915759

S AlSalhi M, Devanesan S, E AlZahrani K, AlShebly M, Al-Qahtani F, Farhat K, et al. Impact of Diabetes Mellitus on Human Erythrocytes: Atomic Force Microscopy and Spectral Investigations. Int J Environ Res Public Health. 2018;15(11):2368. DOI: 10.3390/ijerph15112368. PMID: 30373127; PMCID: PMC6266196.

Suresh S, Rajvanshi PK, Noguchi CT. The Many Facets of Erythropoietin Physiologic and Metabolic Response. Front Physiol. 2020; 10:1534. DOI: 10.3389/fphys.2019.01534. PMID: 32038269; PMCID: PMC6984352

Kuo SC, Li Y, Cheng KC, Niu CS, Cheng JT, Niu HS. Investigation of the pronounced erythropoietin-induced reduction in hyperglycemia in type 1-like diabetic rats. Endocr J. 2018;65(2):181-191. DOI: 10.1507/endocrj. EJ17-0353. Epub 2017 Nov 3. PMID: 29109360.

Fernandez-Reyes MJ, Selgas R, Bajo MA, Jimenez C, Del Peso G, Sanchez MC, et al. Increased response to subcutaneous erythropoietin on type I diabetic patients on CAPD: ¿is there a synergistic effect with insulin? Perit Dial Int. 1995;15(6):231-235. PMID: 7578499.

Aoki I, Taniyama M, Toyama K, Homori M, Ishikawa K. Stimulatory effect of human insulin on erythroid progenitors (CFU-E and BFU-E) in human CD34+ separated bone marrow cells and the relationship between insulin and erythropoietin. Stem Cells. 1994;12(3):329-338. DOI: 10.1002/stem.5530120309. PMID: 7521243.

Miyagawa S, Kobayashi M, Konishi N, Sato T, Ueda K. Insulin and insulin-like growth factor I support the proliferation of erythroid progenitor cells in bone marrow through the sharing of receptors. Haematol. 2000;109(3):555-562. DOI: 10.1046/j.1365-2141.2000.02047. x. PMID: 10886204.

Masuda S, Chikuma M, Sasaki R. Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes. Brain Res. 1997;746(1-2):63-70. DOI: 10.1016/s0006-8993(96)01186-9. PMID: 9037485.

Tóthová Z, Šemeláková M, Solárová Z, Tomc J, Debeljak N, Solár P. The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization. Int J Mol Sci. 2021;22(14):7682. DOI: 10.3390/ijms22147682. PMID: 34299300; PMCID: PMC8307237.

Pan Y, Yang XH, Guo LL, Gu YH, Qiao QY, Jin HM. Erythropoietin Reduces Insulin Resistance via Regulation of Its Receptor-Mediated Signaling Pathways in db/db Mice Skeletal Muscle. Int J Biol Sci. 2017;13(10):1329-1340. DOI: 10.7150/ijbs.19752. PMID: 29104499; PMCID: PMC5666531

Abdelrahman A, Mahmoud AA, Lamie Fanous Y, Abd Elhaliem NG, Elalaf H. Impact of erythropoietin and myoinositol versus metformin on insulin resistance in a rat model of polycystic ovary syndrome. Arch Physiol Biochem. 2021 Jul 23:1-12. DOI: 10.1080/13813455.2021.1949023. Epub ahead of print. PMID: 34297646.