A Male Patient Diagnosed with HER-2 Negative Breast Cancer and Brain Metastasis: A Case Report

Resumen

Globally, Male Breast Cancer (MBC) is so thin on the ground. Only a few discussions are currently available. Advanced cases lead to metastases, including brain metastases (BMBC). A 55 yo male experienced loss of consciousness and troubles in raising his right arms. There was a painless lump on the right breast, 5cms in diameter. Patient underwent modified radical mastectomy. Tissue biopsy showed invasive ductal carcinoma, ER+, PR+, HER-2-, Ki67+. Brain MRI depicted contrast enhancement in the right subcortical frontoparietal lobe. Patient died from septic shock due to recurrent pneumonia. The patient received treatments according to established guidelines. However, BM still developed within 20 months. This is considered a distinct phenomenon since BMBC is commonly caused by HER-2+ BC. Underlying mechanisms might be due to different signaling pathways. Although MBC shows many similar aspects to female breast cancer (FBC), distinctive characteristics should be the genesis of further discussion.