Analysis of the Relationship Between Soluble Cd40 Ligand and Homeostasis Model Assessment of Insulin Resistance in Obese Non-Diabetic Subjects

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Publicado: Dec 13, 2024
Palabras clave:
Obesity, HOMA-IR, sCD40L

Contenido principal del artículo

Nur Ismi
Deparment of Biomedical Science, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Uleng Bahrun
Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
Liong Boy Kurniawan
Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
Andi Alfian Zainuddin
Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Siti Rafiah
Department of Anatomi, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Himawan Sanusi
Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Resumen

Obesity is a complex multifactorial disease characterized by the accumulation of body fat, leading to adverse effects on one’s well-being. Obesity has a strong association with insulin resistance. Insulin resistance can lead to a range of health issues, including type II diabetes mellitus, cardiovascular disease, and other metabolic syndrome diseases. A method that can be employed to evaluate insulin resistance is the measurement of HOMA-IR. sCD40L is the soluble form of the CD40L molecule released on the cell surface through proteolysis. There is evidence that the sCD40L level is a strong predictor of cardiovascular risk, and enhanced levels of CD40L were reported in patients with hypercholesterolemia, diabetes mellitus, and acute coronary syndromes.

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Cómo citar
Ismi, N. ., Bahrun, U. ., Kurniawan, L. B. ., Zainuddin, A. A. ., Rafiah, S. ., & Sanusi, H. . (2024). Analysis of the Relationship Between Soluble Cd40 Ligand and Homeostasis Model Assessment of Insulin Resistance in Obese Non-Diabetic Subjects. Gaceta Médica De Caracas, 132(4). Recuperado a partir de http://caelum.ucv.ve/ojs/index.php/rev_gmc/article/view/29955
Número
Vol. 132 Núm. 4 (2024)
Sección
ARTÍCULOS ORIGINALES
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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

Biografía del autor/a

Nur Ismi, Deparment of Biomedical Science, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Uleng Bahrun, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.



Andi Alfian Zainuddin, Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Siti Rafiah, Department of Anatomi, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Himawan Sanusi, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia