CRISPR and gene editing in HIV therapy: A scoping review

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Eduardo Tuta-Quintero
Camila Martínez Ayala
Miguel Ángel Molina Ardila
Rodrigo Sanabria Sarmiento
Carlos Felipe Gonzalez Sotelo
Giannella Cianci De León
Daniela F. Pérez Mantilla
Santiago Rhenals Acuña
Estefanía Collazos Bahamon
Yesid Fabian Mantilla Flórez
Alejandro Rueda Rodríguez
Juan Pimentel

Resumen

Human immunodeficiency virus (HIV) is nowadays one of the major health problems worldwide. Several strategies have been explored for the eradication of latent HIV-1 reservoirs, current antiretroviral therapy stops the progression of HIV disease, however, as new therapies are being developed, CRISPR (clustered regularly interspaced short palindromic repeats) systems have recently been used as a genome editing technique. CRISPR is becoming progressively one of the possible cures, although it remains experimental, for HIV in medical research. This systematic review summarizes literature evidence of CRISPR gene editing in HIV/AIDS therapy. This study also identifies the research gaps in the current literature, helping to guide future research.

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Tuta-Quintero, E., Martínez Ayala, C. ., Molina Ardila, M. Ángel ., Sanabria Sarmiento, R. ., Gonzalez Sotelo, C. F. ., Cianci De León, G. ., Pérez Mantilla, D. F. ., Rhenals Acuña, S. ., Collazos Bahamon, E. ., Mantilla Flórez, Y. F. ., Rueda Rodríguez, A. ., & Pimentel, J. . (2023). CRISPR and gene editing in HIV therapy: A scoping review. Gaceta Médica De Caracas, 131(1). Recuperado a partir de http://caelum.ucv.ve/ojs/index.php/rev_gmc/article/view/25815
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