Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go

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Publicado: Jul 11, 2022
Palabras clave:
Colorectal cancer, epigenetics, DNA methylation, histone modification, RNA therapeutics, cancer

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Yudith Annisa Ayu Rezkitha
Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia
https://orcid.org/0000-0001-7600-9114
Camilia Metadea Aji Savitri
Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia
Maria Inge Lusida
Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia
Siprianus Ugroseno Yudho Bintoro
4 Department of Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Lita Diah Rahmawati
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
Reny I’tishom
6 Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia
Muhammad Miftahussurur
7 Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
https://orcid.org/0000-0003-1415-6033

Resumen

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.

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Cómo citar
Ayu Rezkitha, Y. A. ., Aji Savitri, C. M. ., Lusida, M. I. ., Yudho Bintoro, S. . U. ., Rahmawati, L. D. ., I’tishom, R. ., & Miftahussurur, M. . (2022). Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go. Gaceta Médica De Caracas, 130(2). Recuperado a partir de http://caelum.ucv.ve/ojs/index.php/rev_gmc/article/view/24057
Número
Vol. 130 Núm. 2 (2022)
Sección
ARTÍCULOS DE REVISIÓN
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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.