Ghrelin and C-peptide as biomarkers for hypercholesterolemia

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Ghrelin, C-peptide, cholesterol, inflammation, C reactive protein, biomarkers, hypercholesterolemia.

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Drs. Leticia Figueira
Laboratory of Neuropeptides, School of Pharmacy; School of Bioanalysis and Laboratory of Research and Graduate School of Bioanalysis, of Health Sciences, Universidad de Carabobo, Carabobo - Venezuela.
Yaira Mathison
Department of Pharmacology, School of Medicine José María Vargas;
Mariella Pastorello
Laboratory of Neuropeptides, School of Pharmacy ORCID: 0000-0002-2805-3783
María Gabriela Matos
Laboratory of Neuropeptides, School of Pharmacy: ORCID: 0000-0001-7290-5237
Elsa Camacho
Laboratory of Neuropeptides, School of Pharmacy: ORCID: 000-0003-1270-6230
Eduardo Romero
Department of Pharmacology, School of Medicine José María Vargas
Jesús Hernández
Department of Biochemistry, School of Odontology, Universidad Central de Venezuela
María del Rosario Garrido
Laboratory of Neuropeptides, School of Pharmacy
Ellodie Billet
Laboratory of Neuropeptides, School of Pharmacy
Yubizaliz López
Department of Pharmacology, School of Medicine José María Vargas;
Anita Israel
Laboratory of Neuropeptides, School of Pharmacy, ORCID: 0000-0003-1812-0759

Resumen

Inflammation and hypercholesterolemia have been reported as risk factors involved in the pathogenesis of cardiovascular diseases. Ghrelin and its receptors are present in the myocardium and vasculature, were they exert cardio-protector and anti-inflammatory functions. C-peptide is a product of proinsulin that plays a physiological role in different types of cells and has pro and anti-inflammatory properties.

La inflamación y la hipercolesterolemia son considerados factores de riesgo involucrados en la patogénesis de las enfermedades cardiovasculares. La grelina y sus receptores están presentes en el miocardio y la vasculatura, donde ejercen funciones cardioprotectoras y antiinflamatorias. El péptido C es un producto de la proinsulina que juega un papel fisiológico en diferentes tipos de células y tiene propiedades pro y antiinflamatorias.

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Figueira, D. L., Mathison, Y., Pastorello, M., Matos, M. G., Camacho, E., Romero, E., Hernández, J., Garrido, M. del R., Billet, E., López, Y., & Israel, A. (2020). Ghrelin and C-peptide as biomarkers for hypercholesterolemia. Gaceta Médica De Caracas, 128(3), 346–359. Recuperado a partir de http://caelum.ucv.ve/ojs/index.php/rev_gmc/article/view/19366
Número
Vol. 128 Núm. 3 (2020)
Sección
ARTÍCULOS DE REVISIÓN

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