Effect of exogenous melatonin on classification tasks in young adults

Authors

  • Javier Sánchez Betancourt
  • Jorge Alberto Guzmán Cortés
  • Rubén Avilés Reyes
  • Arturo Meza Amaya
  • Sofía Trillo Gabaldón

Keywords:

Melatonin; Abstract thinking; Response times; Dream; Memory

Abstract

Introduction: use of exogenous melatonin has generally been found to successfully treat sleep disturbances. In recent years it has regained interest due to its favorable effects on learning and memory. In this sense, the benefits of melatonin on other types of processes such as cognitive flexibility have not been explored. The objective of the present investigation was to determine the effect of melatonin consumption during one month on these processes in young adults with an average age of 23.5 years. Methodology: the sample consisted of 30 participants who were divided into a control group and an experimental group. The experimental group consumed 10 mg of melatonin daily for 2 months. Every three weeks, both groups were evaluated with computerized Wisconsin card tests and tapping test. Results and conclusions: melatonin had a significant improvement over abstract thinking but not about response times.

Downloads

Download data is not yet available.

References

Wurtman RJ, Zhdanova I. Improvement of sleep quality by melatonin. Lancet. 1995;346(8988):1491. Disponible en: https://doi.org/10.1016/s0140-6736(95)92509-0

Jean-Louis G, von Gizycki H, Zizi F. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res. 1998;25(3):177-183. Disponible en: https://doi:10.1111/j.1600-079x.1998.tb00557.x

Boutin JA, Audinot V, Ferry G, Delagrange P. Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci. 2005;26(8):412-419. Disponible en: https://doi:10.1016/j.tips.2005.06.006

Wade AG, Crawford G, Ford I, et al. Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response. Curr Med Res Opin. 2011;27(1):87-98. Disponible en: https://doi:10.1185/03007995.2010.537317

Dabbeni-Sala F, Di Santo S, Franceschini D, Skaper SD, Giusti P. Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity. FASEB J. 2001;15(1):164-170. Disponible en: https://doi:10.1096/fj.00-0129com

Chacón-Lozsán F, García D, Bonfante R, Daza D, Alvarado L. Efectos conductuales del consumo espontáneo de alcohol en ratones NRMI bajo estrés discontinuo. Arch Venez Farmacol y Ter. 2013;33(2). Disponible en: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0798-02642013000200005

Gutiérrez CI, Carrillo GJ, Urbina-Guanipa O. Caracterización de receptores de melatonina en membranas de linfocitos caprinos. Arch Venez Farmacol y Ter. 2007;26(1). Disponible en: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0798-02642007000100005

Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev. 2017;34:10-22. Disponible en: https://doi:10.1016/j.smrv.2016.06.005

Checa-Ros A, Muñoz-Gallego A, Muñoz-Gallego MLÁ, et al. Clinical Considerations Derived From the Administration of Melatonin to Children With Sleep Disorders. Pediatr Neurol. 2018;78:61-69. Disponible en: https://doi:10.1016/j.pediatrneurol.2017.10.010

Santamaria Loza EC, Pérez Miranda PA, Altamirano Castillo JC, et al. Importancia del cuidado de la calidad del sueño en los pacientes con síndrome metabólico. Revista Latinoamaricana de Hipertensión. 2022;16(5). Disponible en https://doi.org/10.5281/zenodo.6233051

Kundurovic Z, Sofic E. The effects of exogenous melatonin on the morphology of thyrocytes in pinealectomized and irradiated rats. J Neural Transm (Vienna). 2006;113(1):49-58. Disponible en: https://doi:10.1007/s00702-005-0396-z

Chen BH, Park JH, Lee TK, et al. Melatonin attenuates scopolamine-induced cognitive impairment via protecting against demyelination through BDNF-TrkB signaling in the mouse dentate gyrus. Chem Biol Interact. 2018;285:8-13. Disponible en: https://doi:10.1016/j.cbi.2018.02.023

Haridas S, Kumar M, Manda K. Melatonin ameliorates chronic mild stress induced behavioral dysfunctions in mice. Physiol Behav. 2013;119:201-207. Disponible en: https://doi:10.1016/j.physbeh.2013.06.015

Alzoubi KH, Mayyas FA, Mahafzah R, Khabour OF. Melatonin prevents memory impairment induced by high-fat diet: Role of oxidative stress. Behav Brain Res. 2018;336:93-98. Disponible en: https://doi:10.1016/j.bbr.2017.08.047

Baandrup L, Fagerlund B, Glenthoj B. Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo. Eur Arch Psychiatry Clin Neurosci. 2017;267(2):163-171. Disponible en: https://doi:10.1007/s00406-016-0711-8

Brusco LI, Márquez M, Cardinali DP. Monozygotic twins with Alzheimer's disease treated with melatonin: Case report. J Pineal Res. 1998;25(4):260-263. Disponible en: https://doi:10.1111/j.1600-079x.1998.tb00396.x

Mueller ST, Piper BJ. The Psychology Experiment Building Language (PEBL) and PEBL Test Battery. J Neurosci Methods. 2014;222:250-259. Disponible en: https://doi:10.1016/j.jneumeth.2013.10.024

Asayama K, Yamadera H, Ito T, Suzuki H, Kudo Y, Endo S. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch. 2003;70(4):334-341. Disponible en: https://doi:10.1272/jnms.70.334

Rebai R, Jasmin L, Boudah A. The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices. Brain Res Bull. 2017;134:142-150. Disponible en: https://doi:10.1016/j.brainresbull.2017.07.013

Tarkka IM, Hautasaari P. Motor Action Execution in Reaction-Time Movements: Magnetoencephalographic Study. Am J Phys Med Rehabil. 2019;98(9):771-776. Disponible en: https://doi:10.1097/PHM.0000000000001187

Published

2023-04-08

How to Cite

Sánchez Betancourt, J. ., Guzmán Cortés , J. A., Avilés Reyes, R. ., Meza Amaya, A. ., & Trillo Gabaldón, S. . (2023). Effect of exogenous melatonin on classification tasks in young adults. AVFT – Archivos Venezolanos De Farmacología Y Terapéutica, 41(3). Retrieved from http://caelum.ucv.ve/ojs/index.php/rev_aavft/article/view/25999