Immunophenotype as a prognostic predictor in patients with acute myeloid leukemia

Abstract

Objective: To determine whether the expression of specific immunophenotypic markers analyzed by flow cytometry influences the prognosis of patients with Acute Myeloid Leukemia (AML) at the Teodoro Maldonado Carbo Specialty Hospital. Materials and methods: An observational, retrospective study with a non-experimental design was carried out in 52 patients diagnosed with AML evaluated by outpatient service at the "Teodoro Maldonado Carbo" Specialty Hospital, during the period from January 2018 to December 2020. The data from the medical records found in the As400 platform of the aforementioned hospital were used. Results: Of a sample, the overall age was 49.5 years, 67% were of gender. The most frequent markers were: CD117 (75%), and CD34 (73.8%) marking the myeloid lineage as the affected one. Most of the markers showed a weak expression, being CD33 (granulocytic marker) the one that most frequently had a strong expression. Among the markers studied, most did not show a significant correlation with the mortality and complications variables, except for the CD105 marker, which showed a strong positive correlation with mortality. Conclusion: The expression of the CD105 marker was the only one that had a significant correlation with a worse course of the disease, the other markers of the panel did not show greater relevance.