Correction of structural and functional disorders of red blood cells by intravenous laser irradiation of peripheral blood in chronic endometritis

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Abstract

The objective of the research is to assess the possibility of correcting the structural and functional disorders of red blood cells in chronic endometritis using low-intensity laser blood irradiation in standard treatment.

Materials and Methods. Forty-two patients of reproductive age with a verified diagnosis of chronic endometritis in incomplete remission were divided into 2 groups: control, with endoscopic surgery for infertility and receiving drug therapy, and the second patient group, receiving combination treatment supplemented with an additional course of intravenous laser blood irradiation (ILBI)) for 7 days, 25 minutes daily,using the Mulat laser therapy apparatus (Russia) with a wavelength of 0.63 microns and an output power of 1.5-2 mW. The structural and functional properties of erythrocytes were determined based on the content of proteins and lipids in the membranes, the sorption parameters of the membrane, and the parameters of intra-erythrocyte metabolism.

Results. Before the start of traditional treatment, 87.9% of indicators of the structural and functional properties of erythrocytes resulted altered when compared with the values of healthy donors, respectively. The traditional combination treatment brought back to normal 10.3%, corrected 55.2% and left unchanged 34.5% of the parameters changed before treatment. The use of ILBI turned out to be much more effective, as it normalized 58.6%, corrected 37.9%, and left unchanged 3.5% of the indicators.

Keywords: intravenous laser blood irradiation, chronic endometritis, correction of immune disorders.

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References

Eckert L.O., Hawes S.E. Endometritis: The clinical-pathological syndrome // Am J Obstet Gynecol. 2002; 690-5.

Kulakov V.I., Shurshalina A.V. Chronic endometritis as a cause of reproductive dys-function // Gynecology. - 2012. - V. 14, No. 4. - P.16-18.

Sukhikh G.T., Shurshalina A.V. Chronic endometritis: textbook. - M.: GEOTAR-Media, 2013. - 64p.

Konoplia A.A., Karaulov A.V., Konoplia A.I., Gavriliuk V.P. The relationship between the correction of immune and oxidative disorders with the structural and functional properties of erythrocytes in chronic salpingo-oophoritis. - Kursk: Publishing house of SOU HPE KSMU Roszdrav. 2009. - 180 p.

Konoplia A.I., Gavriliuk V.P., Loktionov A.L., Konoplia A.A., Bystrova N.A. Clinical ex-perience in the combined use of immunomodulators, antioxidants, and membrane protec-tors in clinical practice. - Kursk: Publishing house of MUP "Kursk City Printing House", 2015. - 160 p.

Semko G.A. Structural and functional changes in membranes and outer membrane layers of erythrocytes during hyperepidermopoiesis. Ukrainian Biochemical Journal. 1998, 70; 3: 113-8.

Togaibaev A.A., Kurguzkin A.V., Rikun I.V. The endogenous intoxication diagnostic method. Laboratory work. 1988; 9: 22-4.

Dodge G.T., Mitchell C., Hanahan D.J. The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. Arch. Biochem. Biophys. 1963;100:119-30.

Krylov V.I., Vinogradov A.F., Efremova S.I. Thin layer RBC membrane lipid chromatog-raphy. Laboratornoe Delo. 1984; 4: 205-6.

Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bac-teriophage T4. Nature. 1970; 227: 680.

Shishkina L.N., Shevchenko O.G. Erythrocyte lipids, and their functional activity. Ad-vances in modern biology. 2010; 130(6): 587-602.

Pliasunova M.P., Khlybova S.V., Feoktistov A.A., Shardakov V.I. Effects of combina-tion physiotherapy in chronic endometritis: changes in the activity of the inflammatory process. Medical immunology. 2014; 16(6): 587-92.

Konoplia A.A., Gavrish S.A., Loktionov A.L., Bystrova N.A. Clinical and immunological efficacy of Gepon and Cytoflavin in the combination treatment of chronic endometritis. Modern problems of science and education. - 2015, No. 4. Available at: http://www.science-education.ru/127-21216.

Konoplia A.A., Gavrish S.A., Konoplia A.I., Loktionov A.L. Intravenous blood laser irra-diation for the correction of immune disorders in patients with chronic endometritis. Ques-tions of balneology, physiotherapy, and exercise therapy. - 2016. - V. 93, No. 5. - P. 19-22.

Burduli N.M., Raniuk L.G. The effect of laser therapy on the parameters of cellular immunity and the processes of lipid peroxidation in patients with chronic acalculous cholecystitis. Laser therapy. 2006; 3: 22-7.

Elantsev A.B., Mautenbaev A.A. To the question of the mechanism of the immuno-modulating influence of laser light. Allergology and Immunology. 2014; 15(3): 227-8.

Gabueva A.A., Burduli N.M. The effect of low-intensity laser blood irradiation on the level of lactoferrin in patients with community-acquired pneumonia. Questions of balne-ology, physiotherapy, and exercise therapy. 2015; 92(2): 9-11.

King DA, Chi J, Goyal SP, Saif MW. COVID-19 Disease and SARS-CoV-2 Vaccina-tion in Patients with Cancer. Archives of Pharmacology and Therapeutics. 2021 Mar 29;3(1).

Bergeron A, Décary-Hétu D. COVID-19 and the Health of Illicit Substance Users: Pre-liminary Analysis from Illicit Drug Transaction Data.

Seidel M, Pagonas N, Seibert FS, Bauer F, Rohn B, Vlatsas S, Mühlberger D, Nina B, Westhoff TH. The differential impact of aerobic and isometric handgrip exercise on blood pressure variability and central aortic blood pressure. Journal of Hypertension. 2021 Jul 1;39(7):1269-73.

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Published

2023-03-30

How to Cite

Sunyaikina, O. A. ., Konoplya, A. A. ., & Prokofeva, Y. V. . (2023). Correction of structural and functional disorders of red blood cells by intravenous laser irradiation of peripheral blood in chronic endometritis. AVFT – Archivos Venezolanos De Farmacología Y Terapéutica, 40(5). Retrieved from http://caelum.ucv.ve/ojs/index.php/rev_aavft/article/view/25856