Chronic kidney disease-associated pruritus: features and associated factors
Keywords:
Pruritus, chronic kidney disease, features, association factors.Abstract
Introduction: Chronic kidney disease (CKD) is a condition characterized by a gradual loss of kidney function over time due to injured kidneys or when the glomerular filtration rate is less than 60mL/min/1.73 m2, for more than three months. The final stage of renal illness is the deadly stage of severe CKDs, and its occurrence has increased in the previous 30 years. Chronic kidney disease-associated pruritus is an undesirable condition that triggers itching and negatively affects sleep quality. The study aims to evaluate the features of Pruritus associated with CKD and its association with sociodemographic variables. Method: Cross-sectional study of 53 patients with chronic kidney disease collected from Baqubah dialysis center from the period of April 1st, 2020, to September 1st, 2020, inclusion criteria are all patients with chronic kidney disease who suffer from rashes and Pruritus while exclusion criteria are all patients suffer from rashes and Pruritus does not associate to CKD and cause by other conditions. All patients reported their sociodemographic data like age, gender, sleep pattern, the severity of disease, negative affection of sleep quality and location of Pruritus. Results: CKD-associated Pruritus were distributed as follows: of all patients, age 52±6 years old; 83% were 45 years and above and 13% with age 45 years old and below .23% of patients were females and 77% males, in 40% of patients’ Pruritus interfered with their sleep while 60% not. About 40% of patients with pruritic are severe, while 60% of them are not. 62% of pruritic patients occur in the trunk, while 38% occur in the entire body. There was a significant association between the severity of Pruritus with gender, the affected area, and sleep. Conclusion: Utmost communal symptom of skin in ESRD is Pruritus, broadly identified as “uremic pruritus.” Due to there is no correct association with uremia, significant association occur in male, age higher than 45 years, interferes with sleep and predominates in the trunk region.
Downloads
References
Jha, V., Garcia-Garcia, G., Iseki, K., Li, Z., Naicker, S., Plattner, B., Saran, R., Wang, A.Y.M., Yang, C.W. Chronic kidney disease: Global dimension and perspectives. Lancet. 2013, 382, 260–272.
González, A.O., de Francisco, A., Gayoso, P., García, F. Prevalence of chronic renal disease in Spain: Results of the EPIRCE study. Nefrologia. 2010, 30, 78–86.
White, S.L., Chadban, S.J., Jan, S., Chapman, J.R., Cass, A. How can we achieve global equity in provision of renal replacement therapy? Bull. World Health Organ. 2008, 86, 229–237.
Mettang, M., Weisshaar, E. Pruritus: control of itch in patients undergoing dialysis. Skin Therapy Lett. 2010, 15, 1–5.
Mettang, T. Uremic Itch Management. Curr. Probl. Dermatology. 2016, 50, 133–141.
T.A., L. Itch Management in the Elderly. Curr. Probl. Dermatology. 2016, 50, 192–201.
Kimata, N., Fuller, D.S., Saito, A., Akizawa, T., Fukuhara, S., Pisoni, R.L., Robinson, B.M., Akiba, T. Pruritus in hemodialysis patients: Results from the Japanese Dialysis Outcomes and Practice Patterns Study (JDOPPS). Hemodial. Int. 2014, 18, 657–667.
Weiss, M., Mettang, T., Tschulena, U., Weisshaar, E. Health-related quality of life in haemodialysis patients suffering from chronic itch: results from GEHIS (German Epidemiology Haemodialysis Itch Study). Qual. Life Res. 2016, 25, 3097–3106.
Wu, H.Y., Peng, Y. Sen, Chen, H.Y., Tsai, W.C., Yang, J.Y., Hsu, S.P., Pai, M.F., Lu, H.M., Chiang, J.F., Ko, M.J., Wen, S.Y., Chiu, H.C. A comparison of uremic Pruritus in patients receiving peritoneal dialysis and hemodialysis. Med. (United States). 2016, 95.
Min, J.W., Kim, S.H., Kim, Y.O., Jin, D.C., Song, H.C., Choi, E.J., Kim, Y.L., Kim, Y.S., Kang, S.W., Kim, N.H., Yang, C.W., Kim, Y.K. Comparison of uremic Pruritus between patients undergoing hemodialysis and peritoneal dialysis. Kidney Res. Clin. Pract. 2016, 35, 107–113.
Suseł, J., Batycka-Baran, A., Reich, A., Szepietowski, J.C. Uraemic pruritus markedly affects the quality of life and depressive symptoms in haemodialysis patients with end-stage renal disease. Acta Derm. Venereol. 2014, 94, 276–281.
Weiss, M., Mettang, T., Tschulena, U., Passlick-Deetjen, J., Weisshaar, E. Prevalence of chronic itch and associated factors in haemodialysis patients: A representative cross-sectional study. Acta Derm. Venereol. 2015, 95, 816–82.
Ko, M.J., Wu, H.Y., Chen, H.Y., Chiu, Y.L., Hsu, S.P., Pai, M.F., Ju-YehYang, Lai, C.F., Lu, H.M., Huang, S.C., Yang, S.Y., Wen, S.Y., Chiu, H.C., Hu, F.C., Peng, Y. Sen, Jee, S.H. Uremic Pruritus, Dialysis Adequacy, and Metabolic Profiles in Hemodialysis Patients: A Prospective 5-Year Cohort Study. PLoS One. 2013, 8.
Fallahzadeh, M.K., Roozbeh, J., Geramizadeh, B., Namazi, M.R. Interleukin-2 serum levels are elevated in patients with uremic Pruritus: A novel finding with practical implications. Nephrol. Dial. Transplant. 2011, 26, 3338–3344.
Specchio, F., Carboni, I., Chimenti, S., Tamburi, F., Nisticò, S.. Cutaneous manifestations in patients with chronic renal failure on hemodialysis. Int. J. Immunopathol. Pharmacol. 2014, 27, 1–4.
Murtagh, F.E.M., Addington-Hall, J., Higginson, I.J. The Prevalence of Symptoms in End-Stage Renal Disease: A Systematic Review. Adv. Chronic Kidney Dis. 2007, 14, 82–99.
Weiss, M., Weisshaar, E. Qualitative interviews on chronic Pruritus in haemodialysis patients. Acta Derm. Venereol. 2014, 94, 713–714.
Adejumo, O., Akinbodewa, A., Alli, O., Olatunji, A., Ibukun, I. Prevalence, Pattern and Association of Pruritus with Quality of Life in Chronic Kidney Disease Patients Attending Kidney Care Centre, Ondo City, Southwest Nigeria. Ethiop. J. Health Sci. 2016, 26, 549–554.
Rehman, I.U., Munib, S., Ramadas, A., Khan, T.M. Prevalence of chronic kidney disease-associated pruritus, and association with sleep quality among hemodialysis patients in Pakistan. PLoS One. 2018, 13.
Adejumo, O., Madubuko, R., Olokor, A., Aina, O. Skin changes and dermatological life quality index in chronic kidney disease patients in a tertiary hospital in Southern Nigeria. Niger. J. Clin. Pract. 2019, 22, 245–250.
Hu, X., Sang, Y., Yang, M., Chen, X., Tang, W. Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients A meta-analysis of cross-sectional studies. Med. (United States). 2018, 97.
Kim KH, Lee MS, Kim TH, Kang JW, Choi TY, Lee JD. Acupuncture and related interventions for symptoms of chronic kidney disease. Cochrane Database Syst Rev. 2016 Jun 28;(6):CD009440.
Rehman, I.U., Chan, K.G., Munib, S., Lee, L.H., Khan, T.M. The association between CKD-associated Pruritus and quality of life in patients undergoing hemodialysis in Pakistan: A STROBE compliant cross-sectional study. Med. (United States). 2019, 98.
Solak, B., Acikgoz, S.B., Sipahi, S., Erdem, T. Epidemiology and determinants of Pruritus in pre-dialysis chronic kidney disease patients. Int. Urol. Nephrol. 2016, 14, 82–99.
Sukul, N., Speyer, E. Zee, J. Pruritus and patient-reported outcomes in non-dialysis CKD. Clinical Journal of the American Society of Nephrology. 2019, 14, 673–681.
Pisoni, R.L., Wikström, B., Elder, S.J., Akizawa, T., Asano, Y., Keen, M.L., Saran, R., Mendelssohn, D.C., Young, E.W., Port, F.K. Pruritus in haemodialysis patients: International results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol. Dial. Transplant. 2006, 21, 3495–3505.
Narita, I., Alchi, B., Omori, K., Sato, F., Ajiro, J., Saga, D., Kondo, D., Skatsume, M., Maruyama, S., Kazama, J.J., Akazawa, K., Gejyo, F. Etiology and prognostic significance of severe uremic Pruritus in chronic hemodialysis patients. Kidney Int. 2006, 69, 1626–1632.
Noh, S.H., Park, K., Kim, E.J. The incidence of Pruritus and biochemical marker associated with Pruritus in hemodialysis patients. Ann. Dermatol. 2018, 69, 1626–1632.
Tessari, G., Vedove, C.D., Loschiavo, C., Tessitore, N., Rugiu, C., Lupo, A., Girolomoni, G. The impact of Pruritus on quality of life of patients undergoing dialysis: A single-center cohort study. J. Nephrol. 2009, 22, 241–248.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 AVFT – Archivos Venezolanos de Farmacología y Terapéutica
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
