Endothelial protective properties of short-chain peptides that mimic α-helix B of erythropoietin in experimental preeclampsia

Authors

  • Ivan V. Golubev Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia
  • Vladimir V. Gureev Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia
  • Mikhail V. Korokin Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia
  • Anastasia V. Gureeva Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia
  • Adelaida V. Polyanskaya Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia
  • Mikhail V. Pokrovskii Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia
  • Galina A. Lazareva Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia
  • Natalia A. Bystrova Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia

Keywords:

erythropoietin, preeclampsia, endothelial dysfunction, rats, proteinuria, microcirculation

Abstract

Objective. Investigate the endothelioprotective properties of short-chain derivatives of erythropoietin in experimental preeclampsia.

Methodology. The experiment was performed in 100 white female Wistar rats weighing 250-300 g. L-NAME was administered intraperitoneally (25 mg/kg/day) from 14 to 20 days of pregnancy. The studied peptides (50 μg/kg) were administered intraperitoneally once a day from 10 to 20 days of pregnancy. On the 21st day of pregnancy, functional tests and laboratory tests were performed.

Results. Rat pretreatment with the studied peptides reverted pathological changes in experimental ADMA-like preeclampsia. The greatest effect was observed with the peptide with the laboratory code P-αB1. A significant decrease in systolic and diastolic blood pressure was observed, improved microcirculation in the placenta, restoration of the endothelium NO-synthesizing function, and a decrease in proteinuria.

Conclusion. The results of the study are promising for the use of short-chain derivatives of erythropoietin simulating its α-helix B for the correction of morpho-functional changes in experimental preeclampsia and substantiate the desirability of further research in this direction.

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How to Cite

Golubev, I. V., Gureev, V. V., Korokin, M. V., Gureeva, A. V., Polyanskaya, A. V., Pokrovskii, M. V., Lazareva, G. A., & Bystrova, N. A. (2021). Endothelial protective properties of short-chain peptides that mimic α-helix B of erythropoietin in experimental preeclampsia. AVFT – Archivos Venezolanos De Farmacología Y Terapéutica, 39(5). Retrieved from http://caelum.ucv.ve/ojs/index.php/rev_aavft/article/view/21048

Issue

Vol. 39 No. 5 (2020): AVFT-Archivos Venezolanos de Farmacología y Terapéutica

Section

Artículos