1) Investigación >
Artículos Publicados >

Por favor, use este identificador para citar o enlazar este ítem:

Título : Chemotactic activities of Vasoactive Intestinal Peptide, Neuropeptide Y and Substance P in Leishmania braziliensis
Autor : Giammarressi, Michelle
Vanegas, Oriana
Febres, Anthony
Silva-López, Adrian
Díaz-López, Emilia
Ponte-Sucre, Alicia
Palabras clave : VIP
receptor mediated
Fecha de publicación : 24-Jun-2021
Citación : Experimental Parasitology;219:108009, 2020.
Resumen : Cell-cell interaction and active migration (and invasion) of parasites into skin host-cell(s) are key steps for successful infection by Leishmania. Chemotaxis constitutes a primordial chapter of Leishmania-host cell interaction, potentially modulated by neuropeptides released into the skin due, for example, to the noxious stimuli represented by the insect bite. Herein we have evaluated in vitro the effect of sensory (Substance P, SP) and autonomic (Vasoactive Intestinal Peptide, VIP, and Neuropeptide Y, NPY) neuropeptides on parasite taxis, and investigated the potential modulatory effect of SP on Leishmania (Viannia) braziliensis-macrophage interaction. We demonstrated that VIP (10􀀀 10 M) and NPY (10􀀀 9 M) are chemorepellent to the parasites, while SP (10􀀀 8 M) produces a chemoattractant response. SP did not affect macrophage viability but seems to impair parasitemacrophage interaction as it decreased promastigote adherence to macrophages. As this effect is blocked by ([D-Pro 2, D-Trp7,9]-Substance P (10􀀀 6 M), the observed action may be mediated by neurokinin-1 (NK1) transmembrane receptors. VIP and NPY repellent chemotactic effect is impaired by their corresponding receptor antagonists. Additionally, they suggest that SP may be a key molecule to guide promastigote migration towards, and interaction, with dendritic cells and macrophage host cells.
ISSN : 0014-4894
Aparece en las colecciones: Artículos Publicados

Ficheros en este ítem:

Fichero Descripción Tamaño Formato
Giammarressi et al 2020.pdf2.23 MBAdobe PDFVisualizar/Abrir

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.


Valid XHTML 1.0! DSpace Software Copyright © 2002-2008 MIT and Hewlett-Packard - Comentarios