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http://hdl.handle.net/10872/14063
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| Título : | Biological screening of plants of the Venezuelan Amazons |
| Autor : | Jiménez, G.
Hasegawa, Masahisa
Rodríguez, María del C.
Estrada, Omar
Méndez, Jeannette
Castillo, Anibal
González-Mujica, F.
Motta, N.
Vásquez, J.
Romero-Vechione, Eduardo |
| Palabras clave : | Amazonian plants
Brine shrimp lethality test
Cardiovascular activity
Glucose-6-phosphatase
Biological screening |
| Fecha de publicación : | 2001 |
| Editorial : | Journal of Ethno-Parmacology |
| Citación : | Journal of Ethnopharmacology 77 (2001) 77–83 |
| Resumen : | A total of 21 extracts derived from 17 different plant species collected in Venezuelan Amazons have been tested for the
following biological activities: cardiovascular activity, brine shrimp lethality, and inhibitory effects on the hydrolysis of
glucose-6-phosphate in intact and disrupted microsomes. Eight extracts diminished rat blood pressure with or without changes in
heart rate. The fruit extract of Swartzia leptopetala and the leaf and twig extract of Connarus lambertii resulted in death of
experimental animals. The majority of extracts (17 extracts) showed significant toxicity against Artemia salina. Concerning the
hydrolysis of glucose-6-phosphate, better inhibitory effects were observed in intact microsomes than in disrupted ones for all the
extracts, suggesting that these extracts intervene with variable potency in glucose-6-phosphate transport through the microsomal
membrane. |
| URI : | http://hdl.handle.net/10872/14063 |
| ISSN : | 0022-3573 |
| Aparece en las colecciones: | Artículos Publicados
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