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| Título : | Biological activity of Guatteria cardoniana fractions |
| Autor : | Paredes, A.
Hasegawa, Masahisa
Prieto, F.
Méndez, Jeannette
Rodríguez, María del C.
Rodríguez-Ortega, M. |
| Palabras clave : | Annonaceae
Guatteria cardoniana
Antiviral
Sindbis virus |
| Fecha de publicación : | 2001 |
| Editorial : | Journal of Ethno-Pharmacology |
| Citación : | 78 (2001) 129–132 |
| Resumen : | Methanolic extract of leaves and twigs of Guatteria cardoniana R.E. Fries (Annonaceae), a plant from the Venezuelan rain
forest, was separated in alkaloid rich fractions and their biological effect on baby hamster kidney (BHK) cell line was studied. The
initial plant extract (FA) induced cell proliferation, cytotoxicity as well as antiviral activity, depending on the concentration used.
Further separation of this methanolic extract allowed us to separate these biological activities. The fraction with the highest
antiviral activity (F7) was chromatographed and three of the nine alkaloid-rich fractions obtained, retained this activity. One of
them (F711) exhibited the highest inhibitory effect against a neurotropic Sindbis virus (NSV). |
| URI : | http://hdl.handle.net/10872/14060 |
| ISSN : | 0022-3573 |
| Aparece en las colecciones: | Artículos Publicados
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